Set in 1951, the story follows Marcus Messner, the idealistic son of a humble kosher butcher from Newark, N.J. Marcus leaves for Ohio to study at a small, conservative college, where he finds himself at odds with the administration, grapples with anti-Semitism and sexual repression and pines after a troubled girl.

When a disgraced former college professor has a romance with a mysterious younger woman haunted by her dark twisted past, he is forced to confront a shocking secret about his own life that he has kept secret for 50 years.

David Kepesh is growing old. He's a professor of literature, a student of American hedonism, and an amateur musician and photographer. When he finds a student attractive, Consuela, a 24-year-old Cuban, he sets out to seduce her. Along the way, he swims in deeper feelings, maybe he's drowning. She presses him to sort out what he wants from her, and a relationship develops. They talk of traveling. He confides in his friend, George, a poet long-married, who advises David to grow up and grow old. She invites him to meet her family. His own son, from a long-ended marriage, confronts him. Is the elegy for lost relationships, lost possibilities, beauty and time passing, or failure of nerve?